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The Oral Anticonvulsant and Antidepressant Lamictal is an anticonvulsant and antidepressant for the treatment of epilepsy and other mood disorders Thase and Denko, Its generic name is lamotrigine.
Lamictal is an oral anticonvulsant agent that was developed on the basis of the observation that certain antiepileptic drugs can initiate antifolate activity. The drug is derived from certain agents that have an inhibition of dihydrofolate reductase. Lamictal however, has very limited antifolate activity.
As a consequence of possible rashes that are life-threatening that include Stevens-Johnson syndrome as well as epidermal neclysis which is toxic, lamictal has a boxed warning that states that its administration should be discontinued should rashes appear at any stage of its administration.
The only factor that is currently known to effectively predict the severity as well as occurrence of the rashes is age. Pediatric patients have also been shown to be at increased risk. Lamictal has been indicated to be a highly effective anticonvulsant and administered as an adjunctive treatment for various types of refractory partial seizures.
This is for seizures having or not having tonic-clonic seizures that are not generalized. It may be administered to adults for the treatment of partial seizures in patients on monotherapy with an antiepileptic drug that is enzyme-inducing.
Lamictal has been noted to result in an improvement in the quality of life as compared to the administration of placebo. Patients have been noted to experience an improvement in the level of seizure severity, happiness as well as mastery as pointed out by Goa, Ross and Chrisp FDA approved Lamictal for the use in both pediatric as well as adult patients in InFDA approved a chewable Lamictal tablet.
In January ofFDA then approved Lamictal tablet as an adjunctive therapy for use in the treatment of partial seizures in children of two or more than two years. January saw the approval of Lamictal for the monotherapy treatment of patients of sixteen years or older.
This only applies when changing from valpoate therapy. September saw the approval of Lamictal for use in adjunct therapy in the management and treatment of primary generalized tonic-clonic seizures. May saw the approval of the orally disintegrating tablet ODT formulation.
In June ,Lamictal XR which is an extended formulation of the drug for use in patients of 13 years or older was approved by FDA as an adjunctive therapy for the onset of partial seizures having or not having secondary generalization. In FebruaryFDA approved Lamictal as an adjunctive therapy for the treatment of primary generalized tonic-clonic seizures.
In Aprilan extended-release Lamictal was approved by FDA for use on conversion to monotherapy in 13 years old or older patients having partial the safety as well as the efficacy of the extended-release Lamictal has never been established as a simultaneous or initial monotherapy conversion to monotherapy from a two or more AED concomitants.
Lamictal has in the past been administered to patients suffering from bipolar disorder especially acute mania. Lamictal has been approved for both labeled use and unlabeled. The in labeled uses of the drug includes its use in the treatment and management of cyclothymia, which is a mild form of bipolar disorder, the treatment of unipolar depression as well as schizoaffective disorder.
Lamictal can also be used for the treatment of borderline personality disorder. When Lamictal is administered with other anticonvulsants in the treatment of mood disorders, then they are considered to be mood stabilizers. A series of clinical studies have shown that Lamictal is extremely effective in the treatment of depressed as well as cyclic bipolar disorder Keck and McElroy, This is especially true for patients who have partial or totally lack any response to lithium administration.
The drug can either be administered alone or in combination with other mood stabilizers such as lithium.
When administered with Depakote, some precautions must be taken in order to reduce the risks of developing severe rash. Mechanism of action The exact mechanism of action that Lamictal takes is not known GlaxoSmithKline, Several studies however, seems to suggest that Lamictal acts by stabilizing the neuronal membranes through the actions that target the sodium channels that are voltage sensitive.
The blockage of the sodium channels then leads to a reduction in the level of presynaptic release of aspartate and glutamate which subsequently leads to the decrease in the frequency of seizures. The mechanism has been noted to be similar to that of phenytoin and cabamazepine.
Lamictal has very limited or no effect at all on the release of dopamine, GABA, norepinephrine or acetylcholine.Disclaimer: Free essays on Medicine posted on this site were donated by anonymous users and are provided for informational use only.
The free Medicine research paper (Epilepsy Oral essay) presented on this page should not be viewed as a sample of our on-line writing service. Lamictal: The Oral Anticonvulsant and Antidepressant Lamictal is an anticonvulsant and antidepressant for the treatment of epilepsy and other mood disorders .
Epilepsy Epilepsy is a brain disorder in which a person has repeated seizures (convulsions) over time.
Seizures are episodes of disturbed brain activity that cause changes in attention or behavior. Causes Epilepsy occurs when permanent changes in brain tissue cause the brain to be too excitable or jumpy. The free Medicine research paper (Epilepsy Oral essay) presented on this page should not be viewed as a sample of our on-line writing service.
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Aug 08, · neocortical epilepsy – epilepsy that originates in the brain's cortex, or outer layer. Seizures can be either focal or generalized, and may cause strange sensations, hallucinations, or emotional changes.
“Epilepsy is a nervous system disorder that produces sudden, intense bursts of electrical activity in the brain. This abnormal electrical activity in the brain causes seizures, which may briefly upset a person’s muscle control, movement, speech, vision, or awareness.”.